男性の包皮切除（割礼）は女性の子宮頸癌を防ぐ
2002/4/10 割礼をした男性は陰茎のhuman papillomavirus (HPV)感染の危険が低下するため、相手の女性の子宮頸癌の危険も低下する。
Man's Circumcision May Cut Partner's Cancer Risk
Wed Apr 10, 5:27 PM ET
NEW YORK (Reuters Health) - A man who is circumcised appears to
have less risk for contracting penile human papillomavirus (HPV)
infections, which may lead to a reduced risk of cervical cancer
for his female partner.
HPV can cause genital warts in men and women, and has been linked
to cancers of the cervix, vulva, vagina, anus and penis, according
to the study, which is published in the April 11th issue of The
New England Journal of Medicine (news - web sites).
To investigate whether male circumcision might cut the risk of
HPV in both men and women, Dr. Xavier Castellsague of the Hospitalet
de Llobregat in Barcelona, Spain, and an international team of
researchers evaluated the prevalence of HPV infection in more
than 1,900 couples living in five different countries.
Penile HPV was detected in 166 (20%) of the 847 uncircumcised
men and in 16 (6%) of the 292 circumcised men, the authors report.
After adjusting for age of first intercourse and lifetime number
of sexual partners, among other factors, the investigators found
that being circumcised reduced a man's risk of HPV infection by
63%.
In addition, the authors report that monogamous women whose male
partners had six or more sexual partners and were circumcised
had a 58% reduction in their risk for cervical cancer.
"The current study indicates that circumcision of men at
high risk of penile HPV infection may reduce the overall risk
of cervical cancer among their female partners by 50% or more,"
Dr. Hans-Olov Adami of the Karolinska Institute in Stockholm,
Sweden, and Dr. Dimitrios Trichopoulos of the Harvard School of
Public Health in Boston, Massachusetts, write in an accompanying
editorial.
"If we assume that 25% of men around the world are circumcised,
then the general adoption of circumcision might lead to a further
reduction in the incidence of cancer of the cervix of 23% to 43%,"
they add.
Adami and Trichopoulos point out that regular use of condoms may
also prevent the sexual transmission of HPV and therefore prevent
cervical cancer.
"The use of condoms can, at least in theory, be targeted
to men involved in high-risk sexual behavior," they write.
Adami and Trichopoulos conclude that "whether interventions
intended to increase the rate of circumcision are a realistic
and quantitatively important addition to other strategies to combat
cancer of the cervix remains to be documented."
SOURCE: The New England Journal of Medicine 2002;346:1105-1112,
1160-